Structural and Functional Characterization of Anti-A33 Antibodies Reveal a Potent Cross-Species Orthopoxviruses Neutralizer.

Structural and Functional Characterization of Anti-A33 Antibodies Reveal a Potent Cross-Species Orthopoxviruses Neutralizer.

Vaccinia virus A33 is an extracellular enveloped virus (EEV)-specific type II membrane glycoprotein that is essential for efficient EEV formation and long-range viral spread within the host. A33 is a target for neutralizing antibody responses against EEV. In this study, we produced seven murine anti...

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Bibliographic Details
Main Authors: Michael H Matho, Andrew Schlossman, Xiangzhi Meng, Mohammed Rafii-El-Idrissi Benhnia, Thomas Kaever, Mark Buller, Konstantin Doronin, Scott Parker, Bjoern Peters, Shane Crotty, Yan Xiang, Dirk M Zajonc
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-09-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4556652?pdf=render

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