In vivo delivery of CRISPR-Cas9 therapeutics: Progress and challenges

Within less than a decade since its inception, CRISPR-Cas9-based genome editing has been rapidly advanced to human clinical trials in multiple disease areas. Although it is highly anticipated that this revolutionary technology will bring novel therapeutic modalities to many diseases by precisely man...

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Bibliographic Details
Main Authors: Matthew Behr, Jing Zhou, Bing Xu, Hongwei Zhang
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Acta Pharmaceutica Sinica B
Subjects:
LNP
AAV
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521001866