The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation

The adhesion function of the sodium channel beta subunit (β1) contributes to cardiac action potential propagation

Computational modeling indicates that cardiac conduction may involve ephaptic coupling – intercellular communication involving electrochemical signaling across narrow extracellular clefts between cardiomyocytes. We hypothesized that β1(SCN1B) –mediated adhesion scaffolds trans-activating NaV1.5 (SCN...

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Bibliographic Details
Main Authors: Rengasayee Veeraraghavan, Gregory S Hoeker, Anita Alvarez-Laviada, Daniel Hoagland, Xiaoping Wan, D Ryan King, Jose Sanchez-Alonso, Chunling Chen, Jane Jourdan, Lori L Isom, Isabelle Deschenes, James W Smyth, Julia Gorelik, Steven Poelzing, Robert G Gourdie
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-08-01
Series:eLife
Subjects:
gap junctions
arrhythmia
apahptic coupling
cardiac conduction
guinea pig
Online Access:https://elifesciences.org/articles/37610

Internet

https://elifesciences.org/articles/37610

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