Integrative pan cancer analysis reveals epigenomic variation in cancer type and cell specific chromatin domains

The NCI-60 cancer cell line panel covers multiple cancer types but has not been extensively investigated at the epigenetic level. Here, the authors present H3K4me3, H3K27ac, H3K9me3, and H4K20me3 ChIP-Seq analysis of the cell lines, and describe features of chromatin states and integrative analyses...

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Bibliographic Details
Main Authors: Lijin K. Gopi, Benjamin L. Kidder
Format: Article
Language:English
Published: Nature Publishing Group 2021-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-21707-1