The C-terminal random coil region tunes the Ca²⁺-binding affinity of S100A4 through conformational activation.

The C-terminal random coil region tunes the Ca²⁺-binding affinity of S100A4 through conformational activation.

S100A4 interacts with many binding partners upon Ca2+ activation and is strongly associated with increased metastasis formation. In order to understand the role of the C-terminal random coil for the protein function we examined how small angle X-ray scattering of the wild-type S100A4 and its C-termi...

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Bibliographic Details
Main Authors: Annette Duelli, Bence Kiss, Ida Lundholm, Andrea Bodor, Maxim V Petoukhov, Dmitri I Svergun, László Nyitray, Gergely Katona
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4022583?pdf=render

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http://europepmc.org/articles/PMC4022583?pdf=render

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