GRK2-Mediated Crosstalk Between β-Adrenergic and Angiotensin II Receptors Enhances Adrenocortical Aldosterone Production In Vitro and In Vivo

GRK2-Mediated Crosstalk Between β-Adrenergic and Angiotensin II Receptors Enhances Adrenocortical Aldosterone Production In Vitro and In Vivo

Aldosterone is produced by adrenocortical zona glomerulosa (AZG) cells in response to angiotensin II (AngII) acting through its type I receptors (AT<sub>1</sub>Rs). AT<sub>1</sub>R is a G protein-coupled receptor (GPCR) that induces aldosterone via both G proteins and the ada...

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Bibliographic Details
Main Authors: Celina M. Pollard, Jennifer Ghandour, Natalie Cora, Arianna Perez, Barbara M. Parker, Victoria L. Desimine, Shelby L. Wertz, Janelle M. Pereyra, Krysten E. Ferraino, Jainika J. Patel, Anastasios Lymperopoulos
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:International Journal of Molecular Sciences
Subjects:
adrenocortical zona glomerulosa cell
aldosterone
angiotensin ii
β-adrenergic receptor
g protein-coupled receptor-kinase-2
signaling crosstalk
Online Access:https://www.mdpi.com/1422-0067/21/2/574

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https://www.mdpi.com/1422-0067/21/2/574

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