Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis.

Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis.

The CDKN2A/ARF locus encompasses overlapping tumor suppressor genes p16(INK4A) and p14(ARF), which are frequently co-deleted in human malignant mesothelioma (MM). The importance of p16(INK4A) loss in human cancer is well established, but the relative significance of p14(ARF) loss has been debated. T...

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Bibliographic Details
Main Authors: Deborah A Altomare, Craig W Menges, Jinfei Xu, Jianming Pei, Lili Zhang, Ara Tadevosyan, Erin Neumann-Domer, Zemin Liu, Michele Carbone, Ilse Chudoba, Andres J Klein-Szanto, Joseph R Testa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3079727?pdf=render

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http://europepmc.org/articles/PMC3079727?pdf=render

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