The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.

The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate.

NF449, a sulfated compound derived from the antiparasitic drug suramin, was previously reported to inhibit infection by enterovirus A71 (EV-A71). In the current work, we found that NF449 inhibits virus attachment to target cells, and specifically blocks virus interaction with two identified receptor...

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Bibliographic Details
Main Authors: Yorihiro Nishimura, Noel P McLaughlin, Jieyan Pan, Sara Goldstein, Susan Hafenstein, Hiroyuki Shimizu, Jeffrey D Winkler, Jeffrey M Bergelson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-10-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC4592248?pdf=render

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http://europepmc.org/articles/PMC4592248?pdf=render

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