Platelet activating factor enhances synaptic vesicle exocytosis via PKC, elevated intracellular calcium, and modulation of synapsin 1 dynamics and phosphorylation

Platelet activating factor (PAF) is an inflammatory phospholipid signaling molecule implicated in synaptic plasticity, learning and memory and neurotoxicity during neuroinflammation. However, little is known about the intracellular mechanisms mediating PAF’s physiological or pathological effects on...

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Bibliographic Details
Main Authors: Jennetta W Hammond, Shao-Ming eLu, Harris A Gelbard
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-01-01
Series:Frontiers in Cellular Neuroscience
Subjects:
PKC
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00505/full