The Combination of Mitragynine and Morphine Prevents the Development of Morphine Tolerance in Mice

The Combination of Mitragynine and Morphine Prevents the Development of Morphine Tolerance in Mice

Mitragynine (MG) is the major active alkaloid found in Mitragyna speciosa Korth. In the present study, we investigated the enhancement of analgesic action of MG when combined with morphine and the effect of the combination on the development of tolerance towards morphine. Mice were administered intr...

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Bibliographic Details
Main Authors: Sharida Fakurazi, Shamima Abdul Rahman, Mohamad Taufik Hidayat, Hairuszah Ithnin, Mohamad Aris Mohd Moklas, Palanisamy Arulselvan
Format: Article
Language:English
Published: MDPI AG 2013-01-01
Series:Molecules
Subjects:
antinociceptive
cAMP
Mitragyna speciosa
morphine
tolerance
Online Access:http://www.mdpi.com/1420-3049/18/1/666

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http://www.mdpi.com/1420-3049/18/1/666

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