Psoralen Induced Liver Injury by Attenuating Liver Regenerative Capability

Psoralen Induced Liver Injury by Attenuating Liver Regenerative Capability

Psoralen is a major component of the common traditional Chinese medicine Fructus Psoraleae (FP). In this study, we focused on psoralen to explore FP-induced hepatotoxicity and the underlying mechanisms. The acute oral median lethal dose of psoralen in ICR mice was determined to be 1,673 mg/kg. C57BL...

Full description

Bibliographic Details
Main Authors: Wang Zhou, Xi Chen, Guolin Zhao, Dengqiu Xu, Zhenzhou Jiang, Luyong Zhang, Tao Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Pharmacology
Subjects:
hepatotoxicity
psoralen
cycle arrest
liver regeneration
mTOR
mitochondrial damage
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01179/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.01179/full

Similar Items