Transfer of mitochondria from mesenchymal stem cells derived from induced pluripotent stem cells attenuates hypoxia-ischemia-induced mitochondrial dysfunction in PC12 cells

Transfer of mitochondria from mesenchymal stem cells derived from induced pluripotent stem cells attenuates hypoxia-ischemia-induced mitochondrial dysfunction in PC12 cells

Mitochondrial dysfunction in neurons has been implicated in hypoxia-ischemia-induced brain injury. Although mesenchymal stem cell therapy has emerged as a novel treatment for this pathology, the mechanisms are not fully understood. To address this issue, we first co-cultured 1.5 × 105 PC12 cells wit...

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Bibliographic Details
Main Authors: Yan Yang, Gen Ye, Yue-Lin Zhang, Hai-Wei He, Bao-Qi Yu, Yi-Mei Hong, Wei You, Xin Li
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Neural Regeneration Research
Subjects:
apoptosis; brain injury; hypoxia-ischemia; induced pluripotent stem cells; mesenchymal stem cells; mitochondrial membrane potential; mitochondrial transfer; PC12 cells; tunneling nanotubes
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=3;spage=464;epage=472;aulast=Yang

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2020;volume=15;issue=3;spage=464;epage=472;aulast=Yang

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