Intramuscular injection of vectorized-scFvMC1 reduces pathological tau in two different tau transgenic models

Intramuscular injection of vectorized-scFvMC1 reduces pathological tau in two different tau transgenic models

Abstract With evidence supporting the prion-like spreading of extracellular tau as a mechanism for the initiation and progression of Alzheimer’s disease (AD), immunotherapy has emerged as a potential disease-modifying strategy to target tau. Many studies have proven effective to clear pathological t...

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Bibliographic Details
Main Authors: Francesca Vitale, Jasmin Ortolan, Bruce T. Volpe, Philippe Marambaud, Luca Giliberto, Cristina d’Abramo
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Acta Neuropathologica Communications
Subjects:
Vectorized antibodies
AAV
scFv
Tau
Immunotherapy
Intramuscular injection
Online Access:http://link.springer.com/article/10.1186/s40478-020-01003-7

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http://link.springer.com/article/10.1186/s40478-020-01003-7

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