Intervening upregulated SLC7A5 could mitigate inflammatory mediator by mTOR-P70S6K signal in rheumatoid arthritis synoviocytes

Intervening upregulated SLC7A5 could mitigate inflammatory mediator by mTOR-P70S6K signal in rheumatoid arthritis synoviocytes

Abstract Objective The disruption of metabolic events and changes to nutrient and oxygen availability due to sustained inflammation in RA increases the demand of bioenergetic and biosynthetic processes within the damaged tissue. The current study aimed to understand the molecular mechanisms of SLC7A...

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Bibliographic Details
Main Authors: Jing Xu, Congshan Jiang, Yongsong Cai, Yuanxu Guo, Xipeng Wang, Jiaxiang Zhang, Jiawen Xu, Ke Xu, Wenhua Zhu, Si Wang, Fujun Zhang, Manman Geng, Yan Han, Qilan Ning, Peng Xu, Liesu Meng, Shemin Lu
Format: Article
Language:English
Published: BMC 2020-08-01
Series:Arthritis Research & Therapy
Subjects:
SLC7A5
MMPs
mTOR-P70S6K
Fibroblast-like synoviocytes
Rheumatoid arthritis
Online Access:http://link.springer.com/article/10.1186/s13075-020-02296-8

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http://link.springer.com/article/10.1186/s13075-020-02296-8

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