The Pseudomonas aeruginosa protease LasB directly activates IL-1β

The Pseudomonas aeruginosa protease LasB directly activates IL-1β

Background: Pulmonary damage by Pseudomonas aeruginosa during cystic fibrosis lung infection and ventilator-associated pneumonia is mediated both by pathogen virulence factors and host inflammation. Impaired immune function due to tissue damage and inflammation, coupled with pathogen multidrug resis...

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Bibliographic Details
Main Authors: Josh Sun, Doris L. LaRock, Elaine A. Skowronski, Jacqueline M. Kimmey, Joshua Olson, Zhenze Jiang, Anthony J. O'Donoghue, Victor Nizet, Christopher N. LaRock
Format: Article
Language:English
Published: Elsevier 2020-10-01
Series:EBioMedicine
Subjects:
Pseudomonas aeruginosa
Proteolysis
Inflammation
Lung
IL-1β
Metalloprotease inhibitor
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420303601

Internet

http://www.sciencedirect.com/science/article/pii/S2352396420303601

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