Complexation of Z-ligustilide with hydroxypropyl-β-cyclodextrin to improve stability and oral bioavailability

To improve the stability and oral bioavailability of Z-ligustilide (LIG), the inclusion complex of LIG with hydroxypropyl- β-cyclodextrin (HP-β-CD) was prepared by the kneading method and characterized by UV-Vis spectroscopy, differential thermal analysis (DTA) and Fourier transform infrared (FTIR)...

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Bibliographic Details
Main Authors: Lu Yapeng, Liu Siyuan, Zhao Yu, Zhu Li, Yu Shuqin
Format: Article
Language:English
Published: Sciendo 2014-06-01
Series:Acta Pharmaceutica
Subjects:
Online Access:http://www.degruyter.com/view/j/acph.2014.64.issue-2/acph-2014-0012/acph-2014-0012.xml?format=INT