The origins and relatedness structure of mixed infections vary with local prevalence of P. falciparum malaria

The origins and relatedness structure of mixed infections vary with local prevalence of P. falciparum malaria

Individual malaria infections can carry multiple strains of Plasmodium falciparum with varying levels of relatedness. Yet, how local epidemiology affects the properties of such mixed infections remains unclear. Here, we develop an enhanced method for strain deconvolution from genome sequencing data,...

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Bibliographic Details
Main Authors: Sha Joe Zhu, Jason A Hendry, Jacob Almagro-Garcia, Richard D Pearson, Roberto Amato, Alistair Miles, Daniel J Weiss, Tim CD Lucas, Michele Nguyen, Peter W Gething, Dominic Kwiatkowski, Gil McVean, for the Pf3k Project
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-07-01
Series:eLife
Subjects:
malaria
genome
epidemiology
relatedness
Online Access:https://elifesciences.org/articles/40845

Internet

https://elifesciences.org/articles/40845

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