Crizotinib and Sunitinib Induce Hepatotoxicity and Mitochondrial Apoptosis in L02 Cells via ROS and Nrf2 Signaling Pathway

Crizotinib and Sunitinib Induce Hepatotoxicity and Mitochondrial Apoptosis in L02 Cells via ROS and Nrf2 Signaling Pathway

Considerable attention has been raised on crizotinib- and sunitinib-induced hepatotoxicity, but the underlying mechanisms need further examination. In addition, limited therapeutic strategies exist to reduce the liver damage caused by crizotinib and sunitinib. This study investigated the mechanisms...

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Bibliographic Details
Main Authors: Lin Guo, Hui Gong, Ting-Li Tang, Bi-Kui Zhang, Lei-Yi Zhang, Miao Yan
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Pharmacology
Subjects:
crizotinib
sunitinib
hepatotoxicity
ROS
Nrf2
mitochondrial apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.620934/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.620934/full

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