Oxygen-Mediated Suppression of CD8+ T Cell Proliferation by Macrophages: Role of Pharmacological Inhibitors of HIF Degradation

Oxygen-Mediated Suppression of CD8+ T Cell Proliferation by Macrophages: Role of Pharmacological Inhibitors of HIF Degradation

Myeloid cell interactions with cells of the adaptive immune system are an essential aspect of immunity. A key aspect of that interrelationship is its modulation by the microenvironment. Oxygen is known to influence myelosuppression of T cell activation in part via the Hypoxia inducible (HIF) transcr...

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Bibliographic Details
Main Authors: Milos Gojkovic, Pedro P. Cunha, Gabriella S. Darmasaputra, Laura Barbieri, Helene Rundqvist, Pedro Veliça, Randall S. Johnson
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
Nitric oxide
hypoxia
immunosuppression
HIF
myeloid cells
von Hippel-Lindau.
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.633586/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.633586/full

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