Functional identification of catalytic metal ion binding sites within RNA.
The viability of living systems depends inextricably on enzymes that catalyze phosphoryl transfer reactions. For many enzymes in this class, including several ribozymes, divalent metal ions serve as obligate cofactors. Understanding how metal ions mediate catalysis requires elucidation of metal ion...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2005-09-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC1184590?pdf=render |