AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation.

AarF Domain Containing Kinase 3 (ADCK3) Mutant Cells Display Signs of Oxidative Stress, Defects in Mitochondrial Homeostasis and Lysosomal Accumulation.

Autosomal recessive ataxias are a clinically diverse group of syndromes that in some cases are caused by mutations in genes with roles in the DNA damage response, transcriptional regulation or mitochondrial function. One of these ataxias, known as Autosomal Recessive Cerebellar Ataxia Type-2 (ARCA-2...

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Main Authors: Jason K Cullen, Norazian Abdul Murad, Abrey Yeo, Matthew McKenzie, Micheal Ward, Kok Leong Chong, Nicole L Schieber, Robert G Parton, Yi Chieh Lim, Ernst Wolvetang, Ghassan J Maghzal, Roland Stocker, Martin F Lavin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4751082?pdf=render

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http://europepmc.org/articles/PMC4751082?pdf=render

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