Heteroplasmic Variants of Mitochondrial DNA in Atherosclerotic Lesions of Human Aortic Intima

Heteroplasmic Variants of Mitochondrial DNA in Atherosclerotic Lesions of Human Aortic Intima

Mitochondrial dysfunction and oxidative stress are likely involved in atherogenesis. Since the mitochondrial genome variation can alter functional activity of cells, it is necessary to assess the presence in atherosclerotic lesions of mitochondrial DNA (mtDNA) heteroplasmic mutations known to be ass...

Full description

Bibliographic Details
Main Authors: Igor A. Sobenin, Andrey V. Zhelankin, Zukhra B. Khasanova, Vasily V. Sinyov, Lyudmila V. Medvedeva, Maria O. Sagaidak, Vsevolod J. Makeev, Kira I. Kolmychkova, Anna S. Smirnova, Vasily N. Sukhorukov, Anton Y. Postnov, Andrey V. Grechko, Alexander N. Orekhov
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Biomolecules
Subjects:
atherosclerosis
mitochondrial DNA mutations
next generation sequencing
mitochondrial DNA copy number
unaffected intima
fatty infiltration
fatty streaks
lipofibrous plaque
fibrous plaque
Online Access:https://www.mdpi.com/2218-273X/9/9/455

Internet

https://www.mdpi.com/2218-273X/9/9/455

Similar Items