Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice

Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice

New methods to produce large numbers of myeloid progenitor cells, precursors to macrophages (MΦs), by maintaining Hoxb8 transcription factor activity1 has reinvigorated interest in MΦ cell therapies. We generated Hoxb8-dependent myeloid progenitors (HDPs) by transducing lineage-negative bone marrow...

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Bibliographic Details
Main Authors: Simon Lee, Saul Kivimäe, Francis C. Szoka
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Molecular Therapy: Methods & Clinical Development
Subjects:
macrophage
cell therapy
transplantation
myeloid
clodronate
cell survival
Online Access:http://www.sciencedirect.com/science/article/pii/S2329050117300967

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http://www.sciencedirect.com/science/article/pii/S2329050117300967

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