Suppression of TRPV1/TRPM8/P2Y Nociceptors by Withametelin via Downregulating MAPK Signaling in Mouse Model of Vincristine-Induced Neuropathic Pain

Suppression of TRPV1/TRPM8/P2Y Nociceptors by Withametelin via Downregulating MAPK Signaling in Mouse Model of Vincristine-Induced Neuropathic Pain

Vincristine (VCR) is a widely used chemotherapy drug that induced peripheral painful neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential (TRP) channels, purinergic receptor (P2Y), and mitogen-activated protein kinase (MAPK) signaling play a crucial role in...

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Bibliographic Details
Main Authors: Adnan Khan, Bushra Shal, Ashraf Ullah Khan, Rahim Ullah, Muhammad Waleed Baig, Ihsan ul Haq, Eun Kyoung Seo, Salman Khan
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
neuropathic pain
vincristine
withametelin
TRPV1/TRPM8
MAPK
Bax/Bcl-2
Online Access:https://www.mdpi.com/1422-0067/22/11/6084

Internet

https://www.mdpi.com/1422-0067/22/11/6084

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