Adjuvantation of an Influenza Hemagglutinin Antigen with TLR4 and NOD2 Agonists Encapsulated in Poly(D,L-Lactide-Co-Glycolide) Nanoparticles Enhances Immunogenicity and Protection against Lethal Influenza Virus Infection in Mice

Adjuvantation of an Influenza Hemagglutinin Antigen with TLR4 and NOD2 Agonists Encapsulated in Poly(D,L-Lactide-Co-Glycolide) Nanoparticles Enhances Immunogenicity and Protection against Lethal Influenza Virus Infection in Mice

Along with their excellent safety profiles, subunit vaccines are typically characterized by much weaker immunogenicity and protection efficacy compared to whole-pathogen vaccines. Here, we present an approach aimed at bridging this disadvantage that is based on synergistic collaboration between patt...

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Bibliographic Details
Main Authors: Amir Tukhvatulin, Alina Dzharullaeva, Alina Erokhova, Anastasia Zemskaya, Maxim Balyasin, Tatiana Ozharovskaia, Olga Zubkova, Natalia Shevlyagina, Vladimir Zhukhovitsky, Irina Fedyakina, Ivan Pruss, Dmitry Shcheblyakov, Boris Naroditsky, Denis Logunov, Alexander Gintsburg
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Vaccines
Subjects:
TLR4
NOD2
PAMPs
complex adjuvant
synergy
pattern-recognition receptors
Online Access:https://www.mdpi.com/2076-393X/8/3/519

Internet

https://www.mdpi.com/2076-393X/8/3/519

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