Chemical Degradation of Androgen Receptor (AR) Using Bicalutamide Analog—Thalidomide PROTACs

Chemical Degradation of Androgen Receptor (AR) Using Bicalutamide Analog—Thalidomide PROTACs

A series of PROTACs (PROteolysis-TArgeting Chimeras) consisting of bicalutamide analogs and thalidomides were designed, synthesized, and biologically evaluated as novel androgen receptor (AR) degraders. In particular, we found that PROTAC compound <b>13b</b> could successfully demonstrat...

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Bibliographic Details
Main Authors: Ga-Yeong Kim, Chae Won Song, Yo-Sep Yang, Na-Rae Lee, Hyung-Seok Yoo, Seung Hwan Son, Soo Jin Lee, Jong Seon Park, Jong Kil Lee, Kyung-Soo Inn, Nam-Jung Kim
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Molecules
Subjects:
bicalutamide
protein degradation
PROTAC
androgen receptor (AR)
prostate cancer
Online Access:https://www.mdpi.com/1420-3049/26/9/2525

Internet

https://www.mdpi.com/1420-3049/26/9/2525

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