HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

HIV-1 replication complexes accumulate in nuclear speckles and integrate into speckle-associated genomic domains

Early steps of HIV infection of primary human cells remain poorly understood. Here, Francis et al. show that early viral replication complexes accumulate within nuclear speckles, in reliance on viral capsid/host CPSF6 interactions, and preferentially integrate in speckle-associated genomic domains.

Bibliographic Details
Main Authors: Ashwanth C. Francis, Mariana Marin, Parmit K. Singh, Vasudevan Achuthan, Mathew J. Prellberg, Kristina Palermino-Rowland, Shuiyun Lan, Philip R. Tedbury, Stefan G. Sarafianos, Alan N. Engelman, Gregory B. Melikyan
Format: Article
Language:English
Published: Nature Publishing Group 2020-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17256-8

Internet

https://doi.org/10.1038/s41467-020-17256-8

Similar Items