Silencing efficacy prediction: a retrospective study on target mRNA features
Post-transcriptional gene silencing is a widely used method to suppress gene expression. Unfortunately only a portion of siRNAs do successfully reduce gene expression. Target mRNA secondary structures and siRNA-mRNA thermodynamic features are believed to contribute to the silencing activity. However...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Portland Press, Biochemical Society
2015-03-01
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| Series: | Bioscience Reports |
| Subjects: | |
| Online Access: | http://www.bioscirep.org/bsr/035/e185/bsr035e185.htm |