Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids

Modeling Human Cytomegalovirus-Induced Microcephaly in Human iPSC-Derived Brain Organoids

Summary: Although congenital infection by human cytomegalovirus (HCMV) is well recognized as a leading cause of neurodevelopmental defects, HCMV neuropathogenesis remains poorly understood. A major challenge for investigating HCMV-induced abnormal brain development is the strict CMV species specific...

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Bibliographic Details
Main Authors: Guoqiang Sun, Flavia Chiuppesi, Xianwei Chen, Cheng Wang, E Tian, Jenny Nguyen, Mindy Kha, Daniel Trinh, Hannah Zhang, Maria C. Marchetto, Hongjun Song, Guo-Li Ming, Fred H. Gage, Don J. Diamond, Felix Wussow, Yanhong Shi
Format: Article
Language:English
Published: Elsevier 2020-04-01
Series:Cell Reports Medicine
Subjects:
Induced pluripotent stem cells
iPSCs
brain organoids
human cytomegalovirus
microcephaly
neutralizing antibody
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379120300021

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http://www.sciencedirect.com/science/article/pii/S2666379120300021

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