Realtime PCR is more sensitive than multiplex PCR for diagnosis and serotyping in children with culture negative pneumococcal invasive disease.

Realtime PCR is more sensitive than multiplex PCR for diagnosis and serotyping in children with culture negative pneumococcal invasive disease.

BACKGROUND: Pneumococcal serotyping is usually performed by Quellung reaction, considered the gold standard test. However the method cannot be used on culture-negative samples. Molecular methods can be a useful alternative. The aim of the study was to evaluate the use of Multiplex-sequential-PCR (MS...

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Bibliographic Details
Main Authors: Chiara Azzari, Maria Moriondo, Giuseppe Indolfi, Martina Cortimiglia, Clementina Canessa, Laura Becciolini, Francesca Lippi, Maurizio de Martino, Massimo Resti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2824814?pdf=render

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http://europepmc.org/articles/PMC2824814?pdf=render

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