Dopamine-dependent, swimming-induced paralysis arises as a consequence of loss of function mutations in the RUNX transcription factor RNT-1.

Dopamine-dependent, swimming-induced paralysis arises as a consequence of loss of function mutations in the RUNX transcription factor RNT-1.

Dopamine (DA) is a neurotransmitter with actions across phylogeny that modulate core behaviors such as motor activity, reward, attention, and cognition. Perturbed DA signaling in humans is associated with multiple disorders, including addiction, ADHD, schizophrenia, and Parkinson's disease. The...

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Bibliographic Details
Main Authors: Sarah B Robinson, Osama Refai, J Andrew Hardaway, Sarah Sturgeon, Tessa Popay, Daniel P Bermingham, Phyllis Freeman, Jane Wright, Randy D Blakely
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0216417

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https://doi.org/10.1371/journal.pone.0216417

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