Reliable Estimation of CD8 T Cell Inhibition of In Vitro HIV-1 Replication

Reliable Estimation of CD8 T Cell Inhibition of In Vitro HIV-1 Replication

The HIV-1 viral inhibition assay (VIA) measures CD8 T cell-mediated inhibition of HIV replication in CD4 T cells and is increasingly used for clinical testing of HIV vaccines and immunotherapies. The VIA has multiple sources of variability arising from in vitro HIV infection and co-culture of two T...

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Bibliographic Details
Main Authors: Yinyan Xu, Ann Marie Weideman, Maria Abad-Fernandez, Katie R. Mollan, Sallay Kallon, Shahryar Samir, Joanna A. Warren, Genevieve Clutton, Nadia Roan, Adaora A. Adimora, Nancie Archin, JoAnn Kuruc, Cindy Gay, Michael G. Hudgens, Nilu Goonetilleke
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
HIV
VIA
p24
JRCSF
ROC
CD8
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.666991/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.666991/full

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