Complement Component C3 Participates in Early Stages of Niemann–Pick C Mouse Liver Damage

Niemann&#8722;Pick type C (NPC), a lysosomal storage disorder, is mainly caused by mutations in the <i>NPC1</i> gene. Niemann&#8722;Pick type C patients and mice show intracellular cholesterol accumulation leading to hepatic failure with increased inflammatory response. The compl...

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Bibliographic Details
Main Authors: Andrés D. Klein, Javier González de la Vega, Silvana Zanlungo
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:International Journal of Molecular Sciences
Subjects:
Online Access:https://www.mdpi.com/1422-0067/21/6/2127