Functional and structural deficits at accumbens synapses in a mouse model of Fragile X

Functional and structural deficits at accumbens synapses in a mouse model of Fragile X

Fragile X is the most common cause of inherited intellectual disability and a leading cause of autism. The disease is caused by mutation of a single X-linked gene called fmr1 that codes for the Fragile X mental retardation protein (FMRP), a 71 kDa protein, which acts mainly as a translation inhibito...

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Bibliographic Details
Main Authors: Daniela eNeuhofer, Christopher M Henstridge, Barna eDudok, Marja eSepers, Olivier eLassalle, István eKatona, Olivier Jacques José Manzoni
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Fragile X Syndrome
autism
synaptic plasticity
Accumbens
Spike timing-dependent plasticity
Dendritic Spine; Synapse
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00100/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2015.00100/full

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