Facile synthesis of a 3-deazaadenosine phosphoramidite for RNA solid-phase synthesis

Facile synthesis of a 3-deazaadenosine phosphoramidite for RNA solid-phase synthesis

Access to 3-deazaadenosine (c3A) building blocks for RNA solid-phase synthesis represents a severe bottleneck in modern RNA research, in particular for atomic mutagenesis experiments to explore mechanistic aspects of ribozyme catalysis. Here, we report the 5-step synthesis of a c3A phosphoramidite f...

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Bibliographic Details
Main Authors: Elisabeth Mairhofer, Elisabeth Fuchs, Ronald Micura
Format: Article
Language:English
Published: Beilstein-Institut 2016-11-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
deazapurine nucleoside
nucleosidation
protection groups
ribozymes
Online Access:https://doi.org/10.3762/bjoc.12.250

Internet

https://doi.org/10.3762/bjoc.12.250

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