The Pharmacological TAILS of Matrix Metalloproteinases and Their Inhibitors

The Pharmacological TAILS of Matrix Metalloproteinases and Their Inhibitors

Matrix metalloproteinases (MMPs) have been demonstrated to have both detrimental and protective functions in inflammatory diseases. Several MMP inhibitors, with the exception of Periostat<sup>®</sup>, have failed in Phase III clinical trials. As an alternative strategy, recent efforts ha...

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Bibliographic Details
Main Authors: Nabangshu Das, Colette Benko, Sean E. Gill, Antoine Dufour
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Pharmaceuticals
Subjects:
matrix metalloproteinases (MMPs), protease
tissue inhibitors of metalloproteinases (TIMPs), exosite
small molecule inhibitors
monoclonal antibodies
proteomics
N-terminomics
Online Access:https://www.mdpi.com/1424-8247/14/1/31

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https://www.mdpi.com/1424-8247/14/1/31

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