Use of simulated vaginal and menstrual fluids to model in vivo discolouration of silicone elastomer vaginal rings

Use of simulated vaginal and menstrual fluids to model in vivo discolouration of silicone elastomer vaginal rings

Vaginal rings releasing antiretrovirals – either alone or in combination with contraceptive progestins – are being developed for prevention of human immunodeficiency virus (HIV) transmission via vaginal sex. Following Phase I trials, significant discolouration was observed on the surface of investig...

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Bibliographic Details
Main Authors: Clare F. McCoy, Patrick Spence, Yahya H. Dallal Bashi, Diarmaid J. Murphy, Peter Boyd, Bindi Dangi, Tiffany Derrick, Bríd Devlin, Kyle Kleinbeck, R. Karl Malcolm
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:International Journal of Pharmaceutics: X
Subjects:
HIV microbicide
Antiretroviral
Dapivirine
Levonorgestrel
Hormonal contraception
Multipurpose prevention technology
Online Access:http://www.sciencedirect.com/science/article/pii/S2590156721000104

Internet

http://www.sciencedirect.com/science/article/pii/S2590156721000104

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