Orexin/Hypocretin and Histamine Cross-Talk on Hypothalamic Neuron Counts in Mice

Orexin/Hypocretin and Histamine Cross-Talk on Hypothalamic Neuron Counts in Mice

The loss of hypothalamic neurons that produce wake-promoting orexin (hypocretin) neuropeptides is responsible for narcolepsy type 1 (NT1). While the number of histamine neurons is increased in patients with NT1, results on orexin-deficient mouse models of NT1 are inconsistent. On the other hand, the...

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Bibliographic Details
Main Authors: Chiara Berteotti, Viviana Lo Martire, Sara Alvente, Stefano Bastianini, Cristiano Bombardi, Gabriele Matteoli, Hiroshi Ohtsu, Jian-Sheng Lin, Alessandro Silvani, Giovanna Zoccoli
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Neuroscience
Subjects:
orexins/hypocretins
histamine
neurons
narcolepsy
mouse
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2021.660518/full

Internet

https://www.frontiersin.org/articles/10.3389/fnins.2021.660518/full

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