Elucidating the Metabolic Plasticity of Cancer: Mitochondrial Reprogramming and Hybrid Metabolic States

Elucidating the Metabolic Plasticity of Cancer: Mitochondrial Reprogramming and Hybrid Metabolic States

Aerobic glycolysis, also referred to as the Warburg effect, has been regarded as the dominant metabolic phenotype in cancer cells for a long time. More recently, it has been shown that mitochondria in most tumors are not defective in their ability to carry out oxidative phosphorylation (OXPHOS). Ins...

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Bibliographic Details
Main Authors: Dongya Jia, Jun Hyoung Park, Kwang Hwa Jung, Herbert Levine, Benny Abraham Kaipparettu
Format: Article
Language:English
Published: MDPI AG 2018-03-01
Series:Cells
Subjects:
cancer metabolism
Warburg effect
oxidative phosphorylation
OXPHOS
mitochondrial respiration
hybrid metabolic phenotype
metabolic plasticity
tumorigenesis
metastasis
EMT
stemness
Online Access:http://www.mdpi.com/2073-4409/7/3/21

Internet

http://www.mdpi.com/2073-4409/7/3/21

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