Expression of p190 BCR-ABL fusion gene in a patient with chronic myeloid leukemia Expressão do rearranjo gênico BCR-ABL com ponto de quebra na região menor do gene BCR em um paciente com leucemia mielóide crônica

Expression of p190 BCR-ABL fusion gene in a patient with chronic myeloid leukemia Expressão do rearranjo gênico BCR-ABL com ponto de quebra na região menor do gene BCR em um paciente com leucemia mielóide crônica

A minority of chronic myeloid leukemia cases have breakpoints in the minor cluster region (m-bcr) of the BCR-ABL gene. We report on a patient with Ph-positive and m-bcr breakpoint at diagnosis. She was treated with hydroxyurea and interferon-alpha. Two years later, she developed a lymphoid blast cri...

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Bibliographic Details
Main Authors: P. V. B. Carvalho, Gustavo J. Lourenço, Maristela Zocca, K. B. B. Pagnano, Irene Lorand-Metze, Carmino A. De Souza, Carmen S. P. Lima
Format: Article
Language:English
Published: Elsevier 2003-01-01
Series:Revista Brasileira de Hematologia e Hemoterapia
Subjects:
BCR-ABL
leucemia mielóide crônica
cromossomo Ph
p190
p210
p230
FISH
RT-PCR
chronic myeloid leukemia
Ph chromosome
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842003000300009

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842003000300009

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