GM-CSF and IL-33 Orchestrate Polynucleation and Polyploidy of Resident Murine Alveolar Macrophages in a Murine Model of Allergic Asthma

GM-CSF and IL-33 Orchestrate Polynucleation and Polyploidy of Resident Murine Alveolar Macrophages in a Murine Model of Allergic Asthma

Allergic asthma is a chronical pulmonary disease with high prevalence. It manifests as a maladaptive immune response to common airborne allergens and is characterized by airway hyperresponsiveness, eosinophilia, type 2 cytokine-associated inflammation, and mucus overproduction. Alveolar macrophages...

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Bibliographic Details
Main Authors: Katharina M. Quell, Kuheli Dutta, Ülkü R. Korkmaz, Larissa Nogueira de Almeida, Tillman Vollbrandt, Peter König, Ian Lewkowich, George S. Deepe, Admar Vershoor, Jörg Köhl, Yves Laumonnier
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:International Journal of Molecular Sciences
Subjects:
allergic asthma
alveolar macrophages
division defect
polynucleation
mouse model
Online Access:https://www.mdpi.com/1422-0067/21/20/7487

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https://www.mdpi.com/1422-0067/21/20/7487

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