ADGRE1 (EMR1, F4/80) Is a Rapidly-Evolving Gene Expressed in Mammalian Monocyte-Macrophages

ADGRE1 (EMR1, F4/80) Is a Rapidly-Evolving Gene Expressed in Mammalian Monocyte-Macrophages

The F4/80 antigen, encoded by the Adgre1 locus, has been widely-used as a monocyte-macrophage marker in mice, but its value as a macrophage marker in other species is unclear, and has even been questioned. ADGRE1 is a seven transmembrane G protein-coupled receptor with an extracellular domain contai...

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Bibliographic Details
Main Authors: Lindsey A. Waddell, Lucas Lefevre, Stephen J. Bush, Anna Raper, Rachel Young, Zofia M. Lisowski, Mary E. B. McCulloch, Charity Muriuki, Kristin A. Sauter, Emily L. Clark, Katharine M. Irvine, Clare Pridans, Jayne C. Hope, David A. Hume
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Immunology
Subjects:
macrophage
monocyte
bone marrow
F4/80
porcine
ADGRE1/EMR1
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02246/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02246/full

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