SOD1 Lysine 123 Acetylation in the Adult Central Nervous System

SOD1 Lysine 123 Acetylation in the Adult Central Nervous System

Superoxide dismutase 1 (SOD1) knockout (Sod1-/-) mice exhibit an accelerated aging phenotype. In humans, SOD1 mutations are linked to familial amyotrophic lateral sclerosis (ALS), and post-translational modification (PTM) of wild-type SOD1 has been associated with sporadic ALS. Reversible acetylatio...

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Bibliographic Details
Main Authors: Michael Kaliszewski, Austin Kennedy, Shelby Blaes, Robert Shaffer, Andrew Knott, Wenjun Song, Henry Hauser, Blaise Bossy, Ting-Ting Huang, Ella Bossy-Wetzel
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
Acetylation
Astrocytes
Cerebellum
Hippocampus
Neurons
Olfactory Bulb
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00287/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncel.2016.00287/full

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