Mitochondrial Quality Control and Cellular Proteostasis: Two Sides of the Same Coin

Mitochondrial Quality Control and Cellular Proteostasis: Two Sides of the Same Coin

Mitochondrial dysfunction is a hallmark of cardiac pathophysiology. Defects in mitochondrial performance disrupt contractile function, overwhelm myocytes with reactive oxygen species (ROS), and transform these cellular powerhouses into pro-death organelles. Thus, quality control (QC) pathways aimed...

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Bibliographic Details
Main Authors: Justin M. Quiles, Åsa B. Gustafsson
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Physiology
Subjects:
mitochondria
UPS
proteasome
UPR
proteotoxicity
import
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2020.00515/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2020.00515/full

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