Discovery of Potential Natural Dipeptidyl Peptidase-4 Inhibitors for Type-2 Diabetes Treatment via Structure-Based Virtual Screening

Discovery of Potential Natural Dipeptidyl Peptidase-4 Inhibitors for Type-2 Diabetes Treatment via Structure-Based Virtual Screening

Dipeptidyl peptidase IV (DPP-4) is a serine protease that plays a crucial role in glucose metabolism; hence, it is a significant target for type II diabetes mellitus treatment. DPP-4 inhibitors decrease glucose concentrations in such patients by preventing the rapid degradation and thereby lengtheni...

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Bibliographic Details
Main Authors: Sara Ranjbar, Mehrane Mohammadabadi Kamarei, Amirhossein Sakhteman, Mehdi khoshneviszadeh
Format: Article
Language:English
Published: Shiraz University of Medical Sciences 2019-09-01
Series:Trends in Pharmaceutical Sciences
Subjects:
dpp-4 inhibitor
a serine protease
docking
adme properties
drug-likeness
Online Access:https://tips.sums.ac.ir/article_45804_5a22e0bdf4923e970d9bed512059a7e3.pdf

Internet

https://tips.sums.ac.ir/article_45804_5a22e0bdf4923e970d9bed512059a7e3.pdf

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