The Mode of SN38 Derivatives Interacting with Nicked DNA Mimics Biological Targeting of Topo I Poisons

The Mode of SN38 Derivatives Interacting with Nicked DNA Mimics Biological Targeting of Topo I Poisons

The compounds 7-ethyl-9-(<i>N</i>-methylamino)methyl-10-hydroxycamptothecin (<b>2</b>) and 7-ethyl-9-(<i>N</i>-morpholino)methyl-10-hydroxycamptothecin (<b>3</b>) are potential topoisomerase I poisons. Moreover, they were shown to have favorable anti-n...

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Bibliographic Details
Main Authors: Wojciech Bocian, Beata Naumczuk, Magdalena Urbanowicz, Jerzy Sitkowski, Anna Bierczyńska-Krzysik, Elżbieta Bednarek, Katarzyna Wiktorska, Małgorzata Milczarek, Lech Kozerski
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
bioconjugate
camptothecin
DNA complexes
molecular modeling
<sup>1</sup>H/<sup>13</sup>C NMR
DOSY
Online Access:https://www.mdpi.com/1422-0067/22/14/7471

Internet

https://www.mdpi.com/1422-0067/22/14/7471

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