Isolation, cloning and structural characterisation of boophilin, a multifunctional Kunitz-type proteinase inhibitor from the cattle tick.

Inhibitors of coagulation factors from blood-feeding animals display a wide variety of structural motifs and inhibition mechanisms. We have isolated a novel inhibitor from the cattle tick Boophilus microplus, one of the most widespread parasites of farm animals. The inhibitor, which we have termed b...

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Bibliographic Details
Main Authors: Sandra Macedo-Ribeiro, Carla Almeida, Bárbara M Calisto, Thomas Friedrich, Reinhard Mentele, Jörg Stürzebecher, Pablo Fuentes-Prior, Pedro José Barbosa Pereira
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2230226?pdf=render