Machilin A Inhibits Tumor Growth and Macrophage M2 Polarization Through the Reduction of Lactic Acid

Machilin A Inhibits Tumor Growth and Macrophage M2 Polarization Through the Reduction of Lactic Acid

Lactate dehydrogenase A (LDHA) is an important enzyme responsible for cancer growth and energy metabolism in various cancers via the aerobic glycolytic pathway. Here, we report that machilin A (MA), which acts as a competitive inhibitor by blocking the nicotinamide adenine dinucleotide (NAD) binding...

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Bibliographic Details
Main Authors: Tae-Wook Chung, Eun-Yeong Kim, Chang Woo Han, So Young Park, Mi Suk Jeong, Dahye Yoon, Hee-Jung Choi, Ling Jin, Mi-Ju Park, Yun Ju Kwon, Hanna Lee, Keuk-Jun Kim, Kang Hyun Park, Suhkmann Kim, Se Bok Jang, Ki-Tae Ha
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cancers
Subjects:
machilin A (MA)
Warburg effect
cancer metabolism
lactate dehydrogenase
hypoxia
Online Access:https://www.mdpi.com/2072-6694/11/7/963

Internet

https://www.mdpi.com/2072-6694/11/7/963

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