Plasma lipoprotein-X quantification on filipin-stained gels: monitoring recombinant LCAT treatment ex vivo

Plasma lipoprotein-X quantification on filipin-stained gels: monitoring recombinant LCAT treatment ex vivo

Familial LCAT deficiency (FLD) patients accumulate lipoprotein-X (LP-X), an abnormal nephrotoxic lipoprotein enriched in free cholesterol (FC). The low neutral lipid content of LP-X limits the ability to detect it after separation by lipoprotein electrophoresis and staining with Sudan Black or other...

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Bibliographic Details
Main Authors: Lita A. Freeman, Robert D. Shamburek, Maureen L. Sampson, Edward B. Neufeld, Masaki Sato, Sotirios K. Karathanasis, Alan T. Remaley
Format: Article
Language:English
Published: Elsevier 2019-05-01
Series:Journal of Lipid Research
Subjects:
lecithin:cholesterol acyltransferase
familial lecithin:cholesterol acyltransferase deficiency
fish-eye disease
cholesterol
phospholipids
high density lipoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520322744

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http://www.sciencedirect.com/science/article/pii/S0022227520322744

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