The Effects of TGF-β Signaling on Cancer Cells and Cancer Stem Cells in the Bone Microenvironment

The Effects of TGF-β Signaling on Cancer Cells and Cancer Stem Cells in the Bone Microenvironment

Background: Transforming growth factor-β (TGF-β) plays a key role in bone metastasis formation; we hypothesized the possible involvement of TGF-β in the induction of cancer stem cells (CSCs) in the bone microenvironment (micro-E), which may be responsible for chemo-resista...

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Bibliographic Details
Main Authors: Mitsuru Futakuchi, Kris Lami, Yuri Tachibana, Yukari Yamamoto, Masahiro Furukawa, Junya Fukuoka
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:International Journal of Molecular Sciences
Subjects:
bone metastasis
mammary tumor
cancer stem cell
bone microenvironment
tgf-β
non csc
Online Access:https://www.mdpi.com/1422-0067/20/20/5117

Internet

https://www.mdpi.com/1422-0067/20/20/5117

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